Hydrochloric Acid → HCID 68771858、化合物
反応式
[CH3:1][C:2]([N:14]1[C:18]2[CH:19]=[C:20]([CH3:23])[CH:21]=[CH:22][C:17]=2[NH:16][C:15]1=[O:24])([CH3:13])[CH2:3][CH2:4][NH:5]C(=O)OC(C)(C)C.Cl>O1CCOCC1>[NH2:5][CH2:4][CH2:3][C:2]([N:14]1[C:18]2[CH:19]=[C:20]([CH3:23])[CH:21]=[CH:22][C:17]=2[NH:16][C:15]1=[O:24])([CH3:13])[CH3:1]参加物
4
反応条件
- 温度
- 90 °C
実験手順
A solution of 1.50 g (4.5 mmol) tert-butyl [3-methyl-3-(6-methyl-2-oxo-2,3-dihydro-benzimidazol-1-yl)-butyl]-carbamate in 100 mL dioxane is combined with 10 mL 4 molar hydrochloric acid in dioxane and then heated to 90° C. for 90 minutes, during which time a white precipitate settles out. After cooling to ambient temperature the solvent is distilled off and the residue is stirred in diethyl ether. White solid. Yield: 1.04 g (86%; hydrochloride); mass spectroscopy: [M+H]+=234.