化工社化工社 化学情報印刷レポート · 研究参考用
Tetrahydrofuran → Ethyl (2-methoxy-6-nitrophenyl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Diphosgene | HCID 10426 | — |
| 反応物 | 6-Nitro-o-anisidine | HCID 85491 | — |
| 生成物 | Ethyl (2-methoxy-6-nitrophenyl)carbamate | HCID 86603972 | — |
反応手順
17.1 mL (0.141 mol) trichloromethylchloroformate are added dropwise at reflux temperature to a solution of 23.8 g (0.142 mol) 2-methoxy-6-nitro-phenylamine in 300 mL THF and then the mixture is stirred for 4 hours at this temperature. The solvent is distilled off and the residue is stirred with isopropanol, during which time a yellow solid is precipitated. Yield: 25.0 g (73%); mass spectroscopy: [M+H]+=241.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07429583B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-5731544a9aa245a3966584cf36fb4237 |
| 出典メモ | uspto-grants-2008_09 |