2,4-Dichloroquinoline → 4-Chloro-6-methoxyquinoline

HRID 333925

反応式

HRID 333925 の反応式
Cl[C:2]1[CH:11]=[C:10]([Cl:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][O-:14].[Na+]>C1(C)C=CC=CC=1>[Cl:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:13])[CH:8]=2)[N:3]=[CH:2][CH:11]=1

参加物

4

反応物 2

HCID 6075032,4-DichloroquinolineHCID 10942334Sodium Methoxide

生成物 1

HCID 2283484-Chloro-6-methoxyquinoline収率 86%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

2,4-Dichloroquinoline (2.5 g, 12.6 mmol) was dissolved in anhydrous toluene (20 ml), a suspension of sodium methoxide (2.5 g, 46.3 mmol) in anhydrous toluene (20 ml) was added and the mixture was heated under reflux for 16 hours. After cooling to room temperature the suspension was filtered, the filter cake washed once with toluene (50 ml), the combined filtrates were evaporated under reduced pressure to dryness to yield 2.1 g (10.8 mmol, 86%) of a red solid. MS (ES) m/z=193.1 [M+H]+.

後処理

  1. additionwas added
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 16 hours
  4. filtrationwas filtered
  5. washthe filter cake washed once with toluene (50 ml)
  6. customthe combined filtrates were evaporated under reduced pressure to dryness

出典と根拠

ORDレコード
ord-ea9c16e87f9848afa81e95787bee821b
出典データセット
uspto-grants-2014_11
特許番号
US08883791B2

関連ノート

読み込み中…