Triethylamine → (E)-4-Methyl-1-[4-(4-quinolyl)-1-piperidyl]pent-2-en-1-one

HRID 333929ノート

反応式

HRID 333929 の反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:24][CH:25]([CH3:31])/[CH:26]=[CH:27]/[C:28](Cl)=[O:29]>ClCCl>[CH3:24][CH:25]([CH3:31])/[CH:26]=[CH:27]/[C:28]([N:1]1[CH2:2][CH2:3][CH:4]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[CH:9][CH:8]=2)[CH2:5][CH2:6]1)=[O:29]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 10986269(E)-4-methylpent-2-enoyl ChlorideHCID 587708514-(Piperidin-4-yl)quinoline

生成物 1

HCID 56948962(E)-4-Methyl-1-[4-(4-quinolyl)-1-piperidyl]pent-2-en-1-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

実験手順

4-(4-Piperidyl)quinoline (0.1 mmol, 21 mg) was dissolved in dichloromethane (1 ml). Triethylamine (1 ml of a 0.12M solution in dichloromethane) was added, the solution was shaken for 30 seconds and (E)-4-methylpent-2-enoyl chloride was added (1 ml of a 0.12 M solution in dichloromethane. The mixture was shaken for one hour at room temperature and evaporated to dryness under reduced pressure. The residue was purified by preparative HPLC. 5.1 mg were obtained (0.017 mmol, 17%).

後処理

  1. stirringThe mixture was shaken for one hour at room temperature
  2. customevaporated to dryness under reduced pressure
  3. customThe residue was purified by preparative HPLC
  4. custom5.1 mg were obtained (0.017 mmol, 17%)

出典と根拠

ORDレコード
ord-9e5b2cb9e7024cf5a925ac2536913329
出典データセット
uspto-grants-2014_11
特許番号
US08883791B2

反応ノート

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