1-Methoxy-2-propanol → HCID 17750604、化合物

HRID 333930

反応式

HRID 333930 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[CH:3]=1.COCC(O)C.[N:19]1([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:12][C:4]1[CH:3]=[C:2]([N:22]2[CH2:21][CH2:20][N:19]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:24][CH2:23]2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1

参加物

4

反応物 3

HCID 79001-Methoxy-2-propanolHCID 779734-Chloro-2-methylquinolineHCID 143452tert-Butyl piperazine-1-carboxylate

生成物 1

HCID 17750604HCID 17750604、化合物

実験手順

4-Chloro-2-methylquinoline (5 g, 28 mmol) was mixed with 1-methoxy-2-propanol, tert-butyl piperazine-1-carboxylate was added (5.74 g, 30.8 mmol) and the mixture was refluxed for 4.5 hours after which the product started to precipitate. The mixture was concentrated under reduced pressure and left at room temperature for 48 hours. The product was separated by filtration, washed with ethylacetate and dried at 50° C. 4.382 g of a solid were obtained (13.38 mmol, 48%). MS (APCI): m/z=327.9 [M+1]+.

後処理

  1. additionwas added (5.74 g, 30.8 mmol)
  2. temperaturethe mixture was refluxed for 4.5 hours after which the product
  3. customto precipitate
  4. concentrationThe mixture was concentrated under reduced pressure
  5. customThe product was separated by filtration
  6. washwashed with ethylacetate
  7. customdried at 50° C

出典と根拠

ORDレコード
ord-183f7a13eb6341c1a117023f1fbe0cec
出典データセット
uspto-grants-2014_11
特許番号
US08883791B2

関連ノート

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