Hydrochloric Acid → 4-[(1S,4S)-2,5-Diazabicyclo[2.2.1]heptan-5-yl]quinoline hydrochloride

HRID 333942ノート

反応式

HRID 333942 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([N:11]2[CH2:16][C@@H:15]3[CH2:17][C@H:12]2[CH2:13][N:14]3C(OC(C)(C)C)=O)=[CH:3][CH:2]=1.[ClH:25]>O1CCOCC1>[ClH:25].[C@H:15]12[CH2:17][C@H:12]([N:11]([C:4]3[C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[N:1]=[CH:2][CH:3]=3)[CH2:16]1)[CH2:13][NH:14]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86691594tert-Butyl (1S,4S)-5-(4-quinolyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

生成物 1

HCID 668355714-[(1S,4S)-2,5-Diazabicyclo[2.2.1]heptan-5-yl]quinoline hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

tert-Butyl (1S,4S)-5-(4-quinolyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (325 mg from step A) was dissolved in a 4M solution of HCl in anhydrous dioxane (4 ml) and stirred for one hour at room temperature. The volatiles were evaporated under reduced pressure, the residue was triturated two times with diethylether and the supernatant removed. The residue was dried in vacuo to obtain 317 mg of a solid. MS (APCI) m/z=225.9 [M+H]+.

後処理

  1. customThe volatiles were evaporated under reduced pressure
  2. customthe residue was triturated two times with diethylether
  3. customThe residue was dried in vacuo

出典と根拠

ORDレコード
ord-60e96f84bf0f4e4aa2c21824645165de
出典データセット
uspto-grants-2014_11
特許番号
US08883791B2

反応ノート

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