Phosphorus oxide (P4O10) → Ethyl (E)-4,4,5,5,5-pentafluoropent-2-enoate

HRID 333953ノート

反応式

HRID 333953 の反応式
[F:1][C:2]([F:15])([C:11]([F:14])([F:13])[F:12])[CH:3](O)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[F:1][C:2]([F:15])([C:11]([F:12])([F:13])[F:14])/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

3

反応物 2

HCID 14812Phosphorus oxide (P4O10)HCID 21883573Ethyl 4,4,5,5,5-pentafluoro-3-hydroxypentanoate

生成物 1

HCID 15260846Ethyl (E)-4,4,5,5,5-pentafluoropent-2-enoate

反応条件

温度
140 °C

実験手順

Ethyl 4,4,5,5,5-pentafluoro-3-hydroxy-pentanoate (11.9 g from step C) was placed in a 25 ml round-bottom flask and phosphorpentoxid was added in small portions until the educt was almost completely absorbed. The temperature was raised slowly to 140° C. until a brown syrup was obtained. The flask was connected to a distilling apparatus and the product isolated by distillation at reduced pressure (50 mbar, 50° C.). 5.5 g (25.2 mmol, 50% over 2 steps) were obtained which were used directly in the next step.

後処理

  1. customwas almost completely absorbed
  2. customwas obtained
  3. customthe product isolated by distillation at reduced pressure (50 mbar, 50° C.)
  4. custom5.5 g (25.2 mmol, 50% over 2 steps) were obtained which

出典と根拠

ORDレコード
ord-79032a1d84ae4d9f8b79cf1f57bf3fc5
出典データセット
uspto-grants-2014_11
特許番号
US08883791B2

反応ノート

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