tert-Butyl piperazine-1-carboxylate → tert-Butyl 4-(5-chloro-pyrazolo[1,5-a]pyrimidin-7-yl)piperazine-1-carboxylate

関与物質

反応条件

反応手順

5,7-Dichloro-pyrazolo[1,5-a]pyrimidine (980 mg, 5.2 mmol) and tert-butyl piperazine-1-carboxylate (2.3 g, 12.6 mmol) were dissolved in 1-methoxy-2-propanol (40 ml) and heated under microwave irridation at 110° C. for one hour. The solvent was removed under reduced pressure and the residue purified by column chromatography (silica, pentane/ethylacetate). The raw product was crystallized from ethanol to yield 1.23 g of a crystalline solid (3.65 mmol, 70%). MS (APCI): m/z=338.2 [M+1]+.

情報源と証拠