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Sodium hydride → Ethyl acetate hexane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Methyl 2-bromopropionate | HCID 95576 | — |
| 反応物 | 1-Benzyl-2-methyl-1H-indol-4-ol | HCID 10752360 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-[[2-methyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]propanoic acid methyl ester | HCID 10639652 | — |
| 生成物 | Ethyl acetate hexane | HCID 21226206 | 74% |
反応手順
4-Hydroxy-2-methyl-1-(phenylmethyl)-1H-indole (483 mg, 2.0 mmol) was reacted with 82 mg (2.0 mmol) of 60% NaH/mineral oil in 20 mL of DMF and then with 0.22 mL (2.0 mmol) of dl-methyl 2-bromopropionate as described in Example 1, Part E to give after chromatography on silica gel eluting with 20% EtOAc/hexane 480 mg (74% yield) of dl-2-[[2-methyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]propanoic acid methyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733923 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-1c51dd5042944cafbcc75002bd31f9d1 |
| 出典メモ | uspto-grants-1998_03 |