3-Fluoro-4-methylbenzeneboronic acid → 1-(3-Fluoro-4-methyl-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid

反応式

[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[CH:6][C:7]=1[CH3:8].[NH:12]1[CH:16]=[N:15][C:14]([C:17]([O:19]C)=[O:18])=[N:13]1.ClC1C=C(N2C=NC(C(O)=O)=N2)C=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([N:12]2[CH:16]=[N:15][C:14]([C:17]([OH:19])=[O:18])=[N:13]2)[CH:5]=[CH:6][C:7]=1[CH3:8]

参加物

反応物 3

HCID 27826743-Fluoro-4-methylbenzeneboronic acid

HCID 713019271-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

HCID 178499122HCID 178499122、化合物

生成物 1

HCID 866882401-(3-Fluoro-4-methyl-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid

実験手順

This intermediate was prepared from 3-fluoro-4-methylphenylboronic acid and methyl 1,2,4-triazole-3-carboxylate in two steps according to the preparation of 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid.

出典と根拠

ORDレコード: ord-83edebd079c2490eb9b7fe792c23ccf2
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08883789B2

反応ノート

読み込み中…

参加物