1-Boc-3,3-dimethylpiperazine → [2-(3-Chloro-phenyl)-2H-tetrazol-5-yl]-(2,2-dimethyl-piperazin-1-yl)methanone trifluoroacetate
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([C:13]([OH:15])=O)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.C(OC([N:23]1[CH2:28][CH2:27][NH:26][C:25]([CH3:30])([CH3:29])[CH2:24]1)=O)(C)(C)C.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].CC1(C)CNCCN1C(C1N=CN(C2C=CC=CC=2)N=1)=O>>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([C:13]([N:26]3[CH2:27][CH2:28][NH:23][CH2:24][C:25]3([CH3:30])[CH3:29])=[O:15])=[N:9]2)[CH:5]=[CH:6][CH:7]=1参加物
4
反応物 3
生成物 1
実験手順
This intermediate was prepared from 2-(3-chloro-phenyl)-2H-tetrazole-5-carboxylic acid and 3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester in two steps according to the preparation of (2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate.