[2,2-Dimethyl-4-(3-methylamino-4-nitro-benzoyl)-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]-triazol-3-yl)-methanone → [4-(4-Amino-3-methylamino-benzoyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]-triazol-3-yl)-methanone
反応式
[CH3:1][C:2]1([CH3:34])[CH2:7][N:6]([C:8](=[O:20])[C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([NH:18][CH3:19])[CH:10]=2)[CH2:5][CH2:4][N:3]1[C:21]([C:23]1[N:27]=[CH:26][N:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[N:24]=1)=[O:22]>[Ni].CO>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([C:8]([N:6]2[CH2:5][CH2:4][N:3]([C:21]([C:23]3[N:27]=[CH:26][N:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[N:24]=3)=[O:22])[C:2]([CH3:34])([CH3:1])[CH2:7]2)=[O:20])=[CH:10][C:11]=1[NH:18][CH3:19]参加物
4
実験手順
A mixture of 445 mg (0.960 mmol) [2,2-dimethyl-4-(3-methylamino-4-nitro-benzoyl)-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]-triazol-3-yl)-methanone and 300 mg Raney nickel in 50 mL MeOH was hydrogenated at RT for 7.5 h. The catalyst was removed by filtration and the solvent was evaporated in vacuo.