Sulfuric Acid → 5-Amino-1-methyl-1H-imidazole-4-carboxamide
反応式
[NH2:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]#[N:9].S(=O)(=O)(O)[OH:11]>>[NH2:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]([NH2:9])=[O:11]参加物
3
実験手順
The cyano group of 5-amino-1-methyl-1H-imidazole-4-carbonitrile 1 is hydrolyzed to the amide in sulfuric acid to give 5-amino-1-methyl-1H-imidazole-4-carboxamide 2 which was cyclized with urea to 9-methyl-1H-purine-2,6(3H,9H)-dione 3. Chlorination of 3 yields 2,6-dichloro-9-methyl-9H-purine 4.
出典と根拠
- ORDレコード
- ord-21dc7c8c8c4445b49ac0c7974c67d7ff
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883799B2
反応ノート
読み込み中…