関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | Thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione | HCID 7059273 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 7-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dione | HCID 18326427 | 60% |
反応手順
Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (10.38 g, 61.72 mmol) was dissolved in acetic acid (230 mL) and Bromine (11.13 mL, 216 mmol) was added. The reaction was heated at 80° C. for 3.5 h. Complete reaction was confirmed by LCMS. The reaction mixture was poured onto ice water slowly and filtered off the precipitate which was dried overnight under vacuum to give 7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (9.1 g, 60% yield)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08883799B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-2b62709c92634f6d93054bc037e3db69 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
