(1,1'-Biphenyl)-2-carboxaldehyde → 1-(Biphenyl-2-ylmethyl)-4-(2-isopropylphenyl)piperazine

HRID 334282

反応式

HRID 334282 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)([CH3:3])[CH3:2].[C:16]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:17]([CH:22]=O)=[CH:18][CH:19]=[CH:20][CH:21]=1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+].C1(C2C=CC=CC=2)C=CC=CC=1CN1CCN(C2C=CC=CC=2)CC1>>[C:16]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH2:22][N:13]1[CH2:12][CH2:11][N:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:1]([CH3:3])[CH3:2])[CH2:15][CH2:14]1

参加物

5

反応物 4

HCID 121052(1,1'-Biphenyl)-2-carboxaldehydeHCID 36088221-(2-Isopropylphenyl)piperazineHCID 5049666Sodium triacetoxyborohydrideHCID 716025231-(Biphenyl-2-ylmethyl)-4-phenylpiperazine

生成物 1

HCID 716783431-(Biphenyl-2-ylmethyl)-4-(2-isopropylphenyl)piperazine

実験手順

100 mg of the target compound (0.27 mmol, 49.1%) was obtained using 1-(2-isopropylphenyl)piperazine (223 mg, 1.09 mmol), biphenyl-2-carbaldehyde (100 mg, 0.55 mmol) and NaBH(OAc)3 (355 mg, 1.65 mmol) according to the synthesis method of Compound 1.

出典と根拠

ORDレコード
ord-433ba77554b646d7b7dc81591e08f6bd
出典データセット
uspto-grants-2014_11
特許番号
US08883796B2

関連ノート

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