1-(2-Methoxyphenyl)piperazine → 1-(2'-Chlorobiphenyl-2-ylmethyl)-4-(2-methoxyphenyl)piperazine

HRID 334286

反応式

HRID 334286 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]1[C:23]([CH:28]=O)=[CH:24][CH:25]=[CH:26][CH:27]=1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+].C1(C2C=CC=CC=2)C=CC=CC=1CN1CCN(C2C=CC=CC=2)CC1>>[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH2:28][N:12]1[CH2:13][CH2:14][N:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[CH2:10][CH2:11]1

参加物

5

反応物 4

HCID 13461-(2-Methoxyphenyl)piperazineHCID 13923752'-Chloro-[1,1'-biphenyl]-2-carbaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 716025231-(Biphenyl-2-ylmethyl)-4-phenylpiperazine

生成物 1

HCID 716026881-(2'-Chlorobiphenyl-2-ylmethyl)-4-(2-methoxyphenyl)piperazine

実験手順

69 mg of the target compound (0.18 mmol, 21.7%) was obtained using 1-(2-methoxyphenyl)piperazine (311 mg, 1.62 mmol), 2′-chlorobiphenyl-2-carbaldehyde (175 mg, 0.81 mmol) and NaBH(OAc)3 (523 mg, 2.43 mmol) according to the synthesis method of Compound 1.

出典と根拠

ORDレコード
ord-413b741224ef49df82953419bac9267d
出典データセット
uspto-grants-2014_11
特許番号
US08883796B2

関連ノート

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