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1-(2,4-Xylyl)piperazine → 1-(Biphenyl-3-ylmethyl)-4-(2,4-dimethylphenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| 反応物 | 3-Phenylbenzaldehyde | HCID 121053 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 1-(Biphenyl-2-ylmethyl)-4-phenylpiperazine | HCID 71602523 | — |
| 生成物 | 1-(Biphenyl-3-ylmethyl)-4-(2,4-dimethylphenyl)piperazine | HCID 71678686 | — |
反応手順
156.4 mg of the target compound (0.44 mmol, 53.7%) was obtained using 1-(2,4-dimethylphenyl)piperazine (312 mg, 1.64 mmol), biphenyl-3-carbaldehyde (150 mg, 0.82 mmol) and NaBH(OAc)3 (529 mg, 2.46 mmol) according to the synthesis method of Compound 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08883796B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-0776b5dba57f4d71a62692714120fb6f |
| 出典メモ | uspto-grants-2014_11 |