Potassium Carbonate → 4-{(4-(4-Chlorophenyl)pyridin-2-yl)amino}benzamide

HRID 33446

反応式

HRID 33446 の反応式
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=O.[N+]([O-])(O)=O.[C:19]([NH:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=1)(=[NH:21])N.[C:32](=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[CH:4]=[CH:3][N:21]=[C:19]([NH:22][C:23]3[CH:24]=[CH:25][C:26]([C:27]([NH2:29])=[O:28])=[CH:30][CH:31]=3)[CH:32]=2)=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 5375260(E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-oneHCID 178512511HCID 178512511、化合物

生成物 1

HCID 691976134-{(4-(4-Chlorophenyl)pyridin-2-yl)amino}benzamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of (2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one (0.10 g, 0.48 mmol), 4-(amidinoamino)benzamide nitrate (0.116 g, 0.48 mmol), and potassium carbonate (0.132 g, 0.96 mmol) in ethanol (10 ml) with was heated to 120° C. overnight in a sealed vessel. The reaction mixture was cooled to room temperature and the resulting solid was collected then washed with ethanol, water, and diethyl ether to provide the title compound as a beige solid, identical in all respects with the compound prepared in Example 1.

後処理

  1. customthe resulting solid was collected
  2. washthen washed with ethanol, water, and diethyl ether

出典と根拠

ORDレコード
ord-c9b5cb1024384becbb40de5f00186850
出典データセット
uspto-grants-2008_09
特許番号
US07429599B2

関連ノート

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