関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydroxylamine | HCID 787 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Methylbenzonitrile | HCID 10721 | — |
| 反応物 | Dichloromethane methanol | HCID 21226129 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-Hydroxy-2-methyl-benzamidine | HCID 3098087 | 100% |
反応手順
A mixture of 2-methyl-benzonitrile (0.950 mL, 8 mmol), hydroxylamine 50% in water (1.6 mL, 24 mmol) and EtOH (8 mL) was heated at 70° C. for 48 h. TLC analysis (DCM/MeOH: 97/3 as eluent) indicates the completion of the reaction. The solvent was removed under reduced pressure to afford 1.2 g of N′-hydroxy-2-methylbenzamidine (Yield: 100%) as a white powder (M.P.=147-148.5° C.). which can be used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08883826B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-10ac7e740fc04206bbb1be61000b08d5 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
