2-Amino-4-chlorophenol → HCID 86086750、化合物
反応式
[CH3:1][O:2][C:3](=[NH:8])[CH2:4][CH2:5][C:6]#[CH:7].N[C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12]C=1O>ClC(Cl)C>[CH2:4]([C:3]1[O:2][C:1]2[CH:10]=[CH:15][C:14]([Cl:16])=[CH:13][C:12]=2[N:8]=1)[CH2:5][C:6]#[CH:7]参加物
4
実験手順
A mixture of pent-4-ynimidic acid methyl ester (142 mg, 1.28 mmol) and 2-amino-4-chlorophenol (227 mg, 1.53 mmol) in dichloroethane (10 mL) was stirred for 2 days under reflux. The solvent was evaporated, the residue was partly dissolved in MeOH and filtered. The filtrate was concentrated, and the resulting crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1) to yield 18 mg (87 μmol, 7%) of 2-(but-3-ynyl)-5-chlorobenzo[d]oxazole.
後処理
- temperatureunder reflux
- customThe solvent was evaporated
- dissolutionthe residue was partly dissolved in MeOH
- filtrationfiltered
- concentrationThe filtrate was concentrated
- customthe resulting crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1)
出典と根拠
- ORDレコード
- ord-f20052d9fbb84bb68e49e1f0bd9dbc96
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883826B2
反応ノート
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