4-Chloropyrimidine → 2-(4-(Pyrimidin-4-yl)but-3-ynyl)benzo[d]oxazole
反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][N:3]=1.[CH2:8]([C:12]1[O:13][C:14]2[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=1)[CH2:9][C:10]#[CH:11]>>[N:5]1[CH:6]=[CH:7][C:2]([C:11]#[C:10][CH2:9][CH2:8][C:12]2[O:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)=[N:3][CH:4]=1参加物
3
実験手順
The title compound was prepared in accordance with the general method of Example 1, from 4-chloropyrimidine (85 mg, 0.74 mmol) and 2-(but-3-ynyl)benzo[d]oxazole (127 mg, 0.74 mmol). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 3:2) to yield 32 mg (128 μmol, 17%) of 2-(4-(pyrimidin-4-yl)but-3-ynyl)benzo[d]oxazole as a white solid.
後処理
- customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 3:2)
出典と根拠
- ORDレコード
- ord-1079d02265d9423b9fd489504d6fecc8
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883826B2
反応ノート
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