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Thionyl Chloride → 2-(Chloromethyl)-1-methylbenzimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (1-methyl-1H-1,3-benzodiazol-2-yl)methanol | HCID 344177 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(Chloromethyl)-1-methylbenzimidazole | HCID 248044 | — |
反応手順
A solution of (1-methyl-1H-benzoimidazol-2-yl)-methanol (500 mg, 3.08 mmol) and SOCl2 (1.1 mL) in DCM (2 mL) was stirred at room temperature for 3 hours. After evaporation of the solvents, 2-chloromethyl-1-methyl-1H-benzoimidazole (556 mg, 3.08 mmol) was obtained and was used without any purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08883826B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-38aee53b7f3342b5a18ec950a90842f0 |
| 出典メモ | uspto-grants-2014_11 |