4-Iodo-2-methyl-1,3-thiazole → 2-(4-(2-Methylthiazol-4-yl)but-3-ynyl)benzo[d]thiazole

反応式

I[C:2]1[N:3]=[C:4]([CH3:7])[S:5][CH:6]=1.[CH2:8]([C:12]1[S:13][C:14]2[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=1)[CH2:9][C:10]#[CH:11]>>[CH3:7][C:4]1[S:5][CH:6]=[C:2]([C:11]#[C:10][CH2:9][CH2:8][C:12]2[S:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)[N:3]=1

参加物

反応物 2

HCID 537067904-Iodo-2-methyl-1,3-thiazole

HCID 570536282-(But-3-yn-1-yl)-1,3-benzothiazole

生成物 1

HCID 116377672-(4-(2-Methylthiazol-4-yl)but-3-ynyl)benzo[d]thiazole収率 53%

実験手順

The title compound was prepared in accordance with the general method of Example 1, from 4-iodo-2-methyl-thiazole (120 mg, 0.53 mmol) and 2-but-3-ynyl-benzo[d]thiazole (100 mg, 0.53 mmol, Example 35(A)). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 4:1) to yield 152 mg (0.28 mmol, 53%) of 2-(4-(2-methylthiazol-4-yl)but-3-ynyl)benzo[d]thiazole as a yellow solid.

後処理

customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 4:1)

出典と根拠

ORDレコード: ord-a47a324c8c9349fc9c0e9c39de2fc567
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08883826B2

反応ノート

読み込み中…