2-Bromopyridine → HCID 66598167、化合物

反応式

Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([N:12]1[CH:20]=[C:19]2[C:14]([C:15]([Cl:21])=[CH:16][CH:17]=[CH:18]2)=[N:13]1)[CH2:9][C:10]#[CH:11]>>[Cl:21][C:15]1[C:14]2[C:19](=[CH:20][N:12]([CH2:8][CH2:9][C:10]#[C:11][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=3)[N:13]=2)[CH:18]=[CH:17][CH:16]=1

参加物

反応物 2

HCID 79732-Bromopyridine

HCID 86086783HCID 86086783、化合物

生成物 1

HCID 66598167HCID 66598167、化合物収率 19.5%

実験手順

The title compound was prepared in accordance with the general method of Example 1, from 2-bromopyridine (36 mg, 0.23 mmol) and 2-but-3-ynyl-7-chloro-2H-indazole (44 mg, 0.21 mmol). Reaction time: 1 day. The crude residue was purified by flash chromatography (DCM/MeOH 98:2) to yield 11 mg (41 μmol, 19%) of 7-chloro-2-(4-(pyridin-2-yl)but-3-ynyl)-2H-indazole as a brown oil.

後処理

customReaction time
custom1 day
customThe crude residue was purified by flash chromatography (DCM/MeOH 98:2)

出典と根拠

ORDレコード: ord-905bc162373949b1ad84c133754baa7a
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08883826B2

反応ノート

読み込み中…

参加物