関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 4-Methylpiperidine | HCID 69381 | — |
| 反応物 | 4-Fluoro-3-nitrobenzyl alcohol | HCID 4167587 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | (4-(4-Methylpiperidin-1-yl)-3-nitrophenyl)methanol | HCID 28963353 | — |
反応手順
A stirred suspension of (4-fluoro-3-nitro-phenyl)-methanol (171 mg, 1 mmol), 4-methyl piperidine (95 mg, 0.96 mmol) PS morpholine (400 mg, 1 mmol), and chloroform (3 mL) was heated at 50° C. for 2 hrs. The reaction was evaporated onto celite and purified by flash chromatography to give [4-(4-methyl-piperidin-1-yl)-3-nitro-phenyl]-methanol (i). 1H NMR (CDCl3, 300 MHz): δ 7.8 (s, 1H), 7.4 (d, 1H), 7.1 (d, 1H), 4.6 (s, 2H), 3.2 (d, 2H), 2.8 (dd, 2H), 1.8-1.3 (m, 5H), 1.0 (d, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07429603B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-ee91f2fb4d5d444dba1ba278f1df6b08 |
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| 出典メモ | uspto-grants-2008_09 |
|---|
