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Water → 5-Bromo-3-(4-fluorophenoxy)picolinonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-Fluorophenol | HCID 9732 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 5-Bromo-3-nitropyridine-2-carbonitrile | HCID 2769698 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Bromo-3-(4-fluorophenoxy)picolinonitrile | HCID 66995028 | 78% |
反応手順
To a solution of 4-fluorophenol (0.49 g, 4.4 mmol) in DMF (10 mL) cooled to 0° C. was added 60% sodium hydride (0.19 g, 4.8 mmol) was added and the reaction was warmed to ambient temperature. 5-Bromo-3-nitropicolinonitrile (1.0 g, 4.4 mmol, solution in 5 mL DMF) and stirred for 3 hours. Poured into water, filtered, washed with water, and dried to yield the title compound (1.0 g, 78%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08883828B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-b58cd363cc784bfa97268f8ce6c04e6e |
| 出典メモ | uspto-grants-2014_11 |