Propanal → HCID 66995125、化合物

HRID 335137

反応式

HRID 335137 の反応式
[CH3:1][C:2]1[C:6]([N+:7]([O-:9])=O)=[C:5]([CH3:10])[O:4][N:3]=1.N1CC[CH2:14][CH2:13][CH2:12]1.C(=O)CC>CCO>[CH3:1][C:2]1[C:6]2=[N+:7]([O-:9])[C:13]([CH3:14])=[CH:12][CH:10]=[C:5]2[O:4][N:3]=1

参加物

5

反応物 3

HCID 527PropanalHCID 8082PiperidineHCID 2614103,5-Dimethyl-4-nitroisoxazole

生成物 1

HCID 66995125HCID 66995125、化合物収率 225%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

3,5-dimethyl-4-nitroisoxazole (2.50 g, 17.6 mmol) in 25 mL EtOH was dissolved. Piperidine (0.174 mL, 1.76 mmol) was added followed by propionaldehyde (1.52 mL, 21.1 mmol). The solution was heated at 90° C. overnight. The solution was concentrated and chromatographed using EtOAc to obtain the title compound (0.650 g, 22.5% yield).

後処理

  1. concentrationThe solution was concentrated
  2. customchromatographed

出典と根拠

ORDレコード
ord-97d920ad523d4714be8f46d5b7eae3d2
出典データセット
uspto-grants-2014_11
特許番号
US08883828B2

関連ノート

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