関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Propanal | HCID 527 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3,5-Dimethyl-4-nitroisoxazole | HCID 261410 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 66995125 | HCID 66995125 | 225% |
反応手順
3,5-dimethyl-4-nitroisoxazole (2.50 g, 17.6 mmol) in 25 mL EtOH was dissolved. Piperidine (0.174 mL, 1.76 mmol) was added followed by propionaldehyde (1.52 mL, 21.1 mmol). The solution was heated at 90° C. overnight. The solution was concentrated and chromatographed using EtOAc to obtain the title compound (0.650 g, 22.5% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08883828B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-97d920ad523d4714be8f46d5b7eae3d2 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
