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Dimethylformamide → 5-(Benzyloxy)-2-chloropyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Chloro-5-hydroxypyridine | HCID 819821 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-(Benzyloxy)-2-chloropyridine | HCID 10013717 | 99.9% |
反応手順
6-Chloropyridin-3-ol (30.00 g, 231.6 mmol), 1-(bromomethyl)benzene (43.57 g, 254.7 mmol), and potassium carbonate (80.01 g, 579.0 mmol) were added to DMF (500 mL) and stirred at ambient temperature overnight. Water was added and extracted with ether. The organic phase was washed with 1M NaOH, dried, filtered, and concentrated to provide the title compound (50.8 g, 99.86% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08883828B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-cf8d630a2c4040d8bce771347a161879 |
| 出典メモ | uspto-grants-2014_11 |