関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formamide | HCID 713 | — |
| 反応物 | Methyl 2-amino-3-thenoate | HCID 78381 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | thieno(2,3-d)pyrimidin-4(3H)-one | HCID 2808547 | 23% |
反応手順
Methyl 2-aminothiophene-3-carboxylate (10 g, 64 mmol) was charged with formamide (50 mL). The reaction was heated at 190° C. under nitrogen for 3 hours. The solution was cooled to room temperature. The slurry was poured into 125 mL of water and extracted with chloroform:isopropyl alcohol mixture (2 times). The solution was concentrated and triturated to afford the title compound (2.25 g, 23%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08883828B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-5deb13959e074614875884ddb94d098d |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
