Formamide → thieno(2,3-d)pyrimidin-4(3H)-one

HRID 335253

反応式

HRID 335253 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([O:9]C)=O.[CH:11]([NH2:13])=O>O>[N:1]1[C:2]2[S:3][CH:4]=[CH:5][C:6]=2[C:7](=[O:9])[NH:13][CH:11]=1

参加物

4

反応物 2

HCID 713FormamideHCID 78381Methyl 2-amino-3-thenoate

生成物 1

HCID 2808547thieno(2,3-d)pyrimidin-4(3H)-one収率 23%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
190 °C

実験手順

Methyl 2-aminothiophene-3-carboxylate (10 g, 64 mmol) was charged with formamide (50 mL). The reaction was heated at 190° C. under nitrogen for 3 hours. The solution was cooled to room temperature. The slurry was poured into 125 mL of water and extracted with chloroform:isopropyl alcohol mixture (2 times). The solution was concentrated and triturated to afford the title compound (2.25 g, 23%).

後処理

  1. temperatureThe solution was cooled to room temperature
  2. extractionextracted with chloroform
  3. concentrationThe solution was concentrated
  4. customtriturated

出典と根拠

ORDレコード
ord-5deb13959e074614875884ddb94d098d
出典データセット
uspto-grants-2014_11
特許番号
US08883828B2

関連ノート

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