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1-Hydroxybenzotriazole → 3-Amino-4-bromo-N-(2-(4-methylpiperazin-1-yl)benzyl)benzamide

HRID 335283
ノート
印刷プレビュー

反応式

HRID 335283 の反応式
CN(C)CCN=C=NCCC.[NH2:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[Br:22])[C:16]([OH:18])=O.[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[CH2:36][NH2:37])[CH2:26][CH2:25]1.C1C=CC2N(O)N=NC=2C=1>C(Cl)Cl>[NH2:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[Br:22])[C:16]([NH:37][CH2:36][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=1[N:27]1[CH2:26][CH2:25][N:24]([CH3:23])[CH2:29][CH2:28]1)=[O:18]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 757711-HydroxybenzotriazoleHCID 27955682-(4-Methyl-1-piperazinyl)benzenemethanamineHCID 34187523-Amino-4-Bromobenzoic AcidHCID 86695678N1,N1-dimethyl-N2-((propylimino)methylene)ethane-1,2-diamine

生成物 1

HCID 866956773-Amino-4-bromo-N-(2-(4-methylpiperazin-1-yl)benzyl)benzamide

試薬・触媒・溶媒 1

HCID 6344
Dichloromethane
溶媒
2 回

実験手順

N1,N1-dimethyl-N2-((propylimino)methylene)ethane-1,2-diamine (0.70 ml, 3.99 mmol) was added to a stirred solution/suspension of 3-amino-4-bromobenzoic acid (719 mg, 3.33 mmol), (2-(4-methylpiperazin-1-yl)phenyl)methanamine (820 mg, 3.99 mmol) and HOBt (140 mg, 1.0 mmol) in dry DCM (20 ml) under argon. After 24 hrs the reaction mixture was diluted with DCM and washed several times with water. The solvent was removed in vacuo and the resulting yellow oil was triturated with DCM/diethyl to give a yellow crystalline powder;

後処理

  1. washwashed several times with water
  2. customThe solvent was removed in vacuo
  3. customthe resulting yellow oil was triturated with DCM/diethyl
  4. customto give a yellow crystalline powder

出典と根拠

ORDレコード
ord-af0775104a0a4395ada3c99c99167468
出典データセット
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08883819B2

反応ノート

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