Hydrochloric Acid → (S)-2-(2-(Methoxymethyl)pyrrolidin-1-yl)ethanamine

HRID 335337ノート

反応式

HRID 335337 の反応式
[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C.Cl>CO>[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[CH2:9][CH2:10][NH2:11]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 71283522(S)-tert-Butyl 2-(2-(methoxymethyl)pyrrolidin-1-yl)ethylcarbamate

生成物 1

HCID 57639942(S)-2-(2-(Methoxymethyl)pyrrolidin-1-yl)ethanamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

A solution of (S)-tert-butyl 2-(2-(methoxymethyl)pyrrolidin-1-yl)ethylcarbamate (step 1) (1.89 g, 7.32 mmol) and in MeOH (5 ml) and treated with 2M HCl in MeOH (10 equivalents) at room temperature over the weekend. The solvent was removed in vacuo to afford the title compound;

後処理

  1. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-1c802c2680ba4f128f90f4fbd50fe2b7
出典データセット
uspto-grants-2014_11
特許番号
US08883819B2

反応ノート

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