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3-Amino-9-ethylcarbazole → (2-Chloro-pyrimidin-4-yl)-(9-ethyl-9H-carbazol-3-yl)-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Amino-9-ethylcarbazole | HCID 8588 | — |
| 反応物 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | (2-Chloro-pyrimidin-4-yl)-(9-ethyl-9H-carbazol-3-yl)-amine | HCID 89654106 | — |
反応手順
Briefly, 2,4-dichloropyrimidine (1) was reacted with 3-amino-9-ethylcarbazole (2) by heating in iso-propanol in the presence of N,N-diisopropylethylamine. Separation of the regioisomers provided the pure 4-substituted pyrimidine derivative (3), which was reacted with 4-(3-Aminopropyl)morpholine (4) in sec-butanol under microwave heating in the presence of N,N-diisopropylethylamine to provide EHop-016 (5).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08884006B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-57420fdc378148f6b93f62605633b0d0 |
| 出典メモ | uspto-grants-2014_11 |