2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetohydrazide → 1-[2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetyl]-2-(2-methyl-1-propylidene)hydrazine

HRID 335475

反応式

HRID 335475 の反応式
[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:17])[C:13]([NH:15][NH2:16])=[O:14])[CH3:2]>CO>[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:17])[C:13]([NH:15][N:16]=[CH:1][CH:3]([CH3:8])[CH3:4])=[O:14])[CH3:2]

参加物

3

反応物 1

HCID 569428732-(2,6-Diethyl-4-methylphenyl)-2-oxoacetohydrazide

生成物 1

HCID 682980701-[2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetyl]-2-(2-methyl-1-propylidene)hydrazine収率 188.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a 300 mL volume three-necked flask, 20.0 g of 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetohydrazide ((12-1)-(11)-39), 76 ml of methanol and 12.3 g of isobutylaldehyde were added and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated under reduced pressure and then hexane was added thereto. The precipitated crystals were collected by filtration and dried under reduced pressure to give 23.2 g of 1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-2-(2-methyl-1-propylidene)hydrazine ((40-a)-(14)-4).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionhexane was added
  3. filtrationThe precipitated crystals were collected by filtration
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-5881e2f4d94b4233b9959bc5775ceb86
出典データセット
uspto-grants-2014_11
特許番号
US08884010B2

関連ノート

読み込み中…