8-Aminoquinoline → HCID 178506091、化合物

HRID 33548

反応式

HRID 33548 の反応式
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([C:11]([F:14])([F:13])[F:12])=[CH:10][C:4]=2[N:3]=1.[NH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[N:24]=[CH:23][CH:22]=[CH:21]2>CCO>[F:12][C:11]([F:14])([F:13])[C:9]1[CH:8]=[CH:7][C:5]2[NH:6][C:2]([NH:15][C:16]3[CH:17]=[CH:18][CH:19]=[C:20]4[C:25]=3[N:24]=[CH:23][CH:22]=[CH:21]4)=[N:3][C:4]=2[CH:10]=1

参加物

4

反応物 2

HCID 113598-AminoquinolineHCID 178506089HCID 178506089、化合物

生成物 1

HCID 178506091HCID 178506091、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-chloro-5-(trifluoromethyl)-1H-benzo[d]imidazole (66 mg, 0.3 mol, prepared according to the procedure described in WO 2004/035549 A1) and 8-aminoquinoline (29 mg, 0.6 mmol, Aldrich) in EtOH (2 mL) was subjected to microwave irradiation at 170° C. with stirring for 30 min. The reaction mixture was allowed to cool to room temperature, the solvent was removed in vacuo and the residue was purified by silica gel chromatography eluting with 3% MeOH/DCM to give the title compound as an amorphous solid. MS (ESI, pos. ion) m/z: 329 (M+1).

後処理

  1. customprepared
  2. customirradiation at 170° C.
  3. customthe solvent was removed in vacuo
  4. customthe residue was purified by silica gel chromatography
  5. washeluting with 3% MeOH/DCM

出典と根拠

ORDレコード
ord-4383ea8f71fc4c7c8aa1855bfedd5fd1
出典データセット
uspto-grants-2008_09
特許番号
US07429608B2

関連ノート

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