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1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole → 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole | HCID 10825849 | — |
| 反応物 | Boron tribromide dichloromethane | HCID 22277759 | — |
| 生成物 | 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole | HCID 10753503 | 84.2% |
反応手順
By the method used in Example 1, Part D, 1.1 g (4.1 mmol) of 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 16.4 mL of 1M BBr3 /CH2Cl2 to give 881 mg (84% yield) of crude 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733923 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-858e366b919f470e923529fff24917ea |
| 出典メモ | uspto-grants-1998_03 |