関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 4-(Pyrrolidin-1-yl)butan-1-amine | HCID 2762762 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Imidazole-1-carboxylic acid (4-pyrrolidin-1-yl-butyl)-amide | HCID 57552584 | — |
反応手順
In a flask under nitrogen, 4-Pyrrolidin-1-yl-butylamine (1.3 equiv, 10.1 g) was taken up in tetrahydrofuran (105 mL, 5 volumes). The mixture was cooled to 0° C. and 1,1′-carbonyldiimidazole (1.3 equiv, 11.6 g) was added. The mixture stirred at 0° C. for 20 minutes, then warmed to 20° C. over 10 minutes and held at 20° C. for 30 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08884025B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-fd652d6a940c4feba76e780d02922705 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
