2-Bromo-1'-propionaphthone → 2-Acetoxy-1-(naphth-1-yl)-1-propanone

HRID 33558ノート

反応式

HRID 33558 の反応式
Br[CH:2]([CH3:15])[C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1)=[O:4].[C:16]([O-:19])(=[O:18])[CH3:17].[Na+]>C(O)C>[C:16]([O:19][CH:2]([CH3:15])[C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1)=[O:4])(=[O:18])[CH3:17]

参加物

4

反応物 2

HCID 2311612-Bromo-1'-propionaphthoneHCID 517045Sodium Acetate

生成物 1

HCID 597968292-Acetoxy-1-(naphth-1-yl)-1-propanone

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-bromo-1-(napth-1-yl)-1-propanone (2 g) and sodium acetate (0.63 g) were boiled under reflux in anhydrous ethanol (10 ml) for 16 hours. The mixture was cooled and evaporated in vacuo. The residue was partitioned between ethyl acetate and water. The organic layer was separated, washed with water, brine, dried with sodium sulphate, filtered and evaporated in vacuo. The title compound was obtained as an oil (0.75 g) following silica gel column chromatography of the residue in 50% dichloromethane in petroleum ether.

後処理

  1. temperatureThe mixture was cooled
  2. customevaporated in vacuo
  3. customThe residue was partitioned between ethyl acetate and water
  4. customThe organic layer was separated
  5. washwashed with water, brine
  6. dry with materialdried with sodium sulphate
  7. filtrationfiltered
  8. customevaporated in vacuo

出典と根拠

ORDレコード
ord-2d9742c4ff344484bc7d573efb547a48
出典データセット
uspto-grants-2008_09
特許番号
US07429607B2

反応ノート

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