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Ethyl Acetate → 2-Dimethylamino-4-(naphth-1-yl)oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | N,N-Dimethylurea | HCID 11737 | — |
| 反応物 | 2-Bromo-1-(1-naphthalenyl)ethanone | HCID 3830513 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Dimethylamino-4-(naphth-1-yl)oxazole | HCID 59796872 | — |
反応手順
1-(α-Bromoacetyl)naphthalene (5 g) and 1,1-dimethylurea (6 g) were stirred in anhydrous dimethylformamide (20 ml) at 105° C. overnight. The mixture was cooled, added to ethyl acetate, washed with sodium bicarbonate solution, water, brine, dried with sodium sulphate, filtered and evaporated in vacuo. The title compound was obtained (0.60 g; m.p. 30-32° C.) following silica gel column chromatography of the residue in dichloromethane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07429607B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-31fee4816a474d2a8db741e1ab749da3 |
| 出典メモ | uspto-grants-2008_09 |