Bromine → 6-Bromo-2-fluoro-3-methoxybenzoic acid
反応式
[F:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:13]Br>C(O)(=O)C.O>[Br:13][C:7]1[C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[C:10]([O:11][CH3:12])=[CH:9][CH:8]=1参加物
5
反応条件
- 温度
- 60 °C
実験手順
To the suspension of 2-fluoro-3-methoxybenzoic acid (20 g, 118 mmol) in Acetic Acid (100 mL) and water (100 mL) at RT, bromine (12.05 mL, 235 mmol) was added dropwise. The reaction mixture was heated for 1 h at 60° C. The reaction was then cooled to RT and white precipitate was filtered. The solid was washed with excess water and dried to give 6-bromo-2-fluoro-3-methoxybenzoic acid (24.68 g, 99 mmol) as a white solid.
後処理
- temperatureThe reaction was then cooled to RT
- filtrationwhite precipitate was filtered
- washThe solid was washed with excess water
- customdried
出典と根拠
- ORDレコード
- ord-5a2957c424af4dc5bd8f88bdb10436ce
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883782B2
反応ノート
読み込み中…