Bromine → 6-Bromo-2-fluoro-3-methoxybenzoic acid

HRID 335974

反応式

HRID 335974 の反応式
[F:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:13]Br>C(O)(=O)C.O>[Br:13][C:7]1[C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[C:10]([O:11][CH3:12])=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 24408BromineHCID 33906792-Fluoro-3-methoxybenzoic acid

生成物 1

HCID 534387896-Bromo-2-fluoro-3-methoxybenzoic acid収率 83.9%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

To the suspension of 2-fluoro-3-methoxybenzoic acid (20 g, 118 mmol) in Acetic Acid (100 mL) and water (100 mL) at RT, bromine (12.05 mL, 235 mmol) was added dropwise. The reaction mixture was heated for 1 h at 60° C. The reaction was then cooled to RT and white precipitate was filtered. The solid was washed with excess water and dried to give 6-bromo-2-fluoro-3-methoxybenzoic acid (24.68 g, 99 mmol) as a white solid.

後処理

  1. temperatureThe reaction was then cooled to RT
  2. filtrationwhite precipitate was filtered
  3. washThe solid was washed with excess water
  4. customdried

出典と根拠

ORDレコード
ord-5a2957c424af4dc5bd8f88bdb10436ce
出典データセット
uspto-grants-2014_11
特許番号
US08883782B2

関連ノート

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