3-Pyridinylboronic acid → (S)-3-(3,3-difluoropyrrolidin-1-yl)-1-fluoro-7-(pyridin-3-yl)-5'-H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine

HRID 336001

反応式

HRID 336001 の反応式
Br[C:2]1[CH:3]=[C:4]2[C@@:15]3([CH2:19][O:18][C:17]([NH2:20])=[N:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[C:10]([F:22])[C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[N:23]1[CH:28]=[CH:27][CH:26]=[C:25](B(O)O)[CH:24]=1.Cl.[F:33][C:34]1([F:39])[CH2:38][CH2:37][NH:36][CH2:35]1>>[F:33][C:34]1([F:39])[CH2:38][CH2:37][N:36]([C:12]2[N:11]=[C:10]([F:22])[C:9]3[O:8][C:5]4[C:4]([C@@:15]5([CH2:19][O:18][C:17]([NH2:20])=[N:16]5)[C:14]=3[CH:13]=2)=[CH:3][C:2]([C:25]2[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=2)=[CH:7][CH:6]=4)[CH2:35]1

参加物

4

反応物 3

HCID 27343783-Pyridinylboronic acidHCID 249034823,3-Difluoropyrrolidine hydrochlorideHCID 58466258(S)-7-bromo-3-chloro-1-fluoro-5'H-spiro[chromeno[2,3-c]pyridine-5,4' oxazol]-2'-amine

生成物 1

HCID 58466280(S)-3-(3,3-difluoropyrrolidin-1-yl)-1-fluoro-7-(pyridin-3-yl)-5'-H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine

実験手順

The title compound was synthesized by steps analogous to those described in method CC4 above, but using (S)-7-bromo-3-chloro-1-fluoro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (prepared by steps analogous to those described in Method BB33) and 3-pyridyl-boronic acid and 3,3-difluoropyrrolidine hydrochloride.

後処理

  1. customprepared by steps analogous to

出典と根拠

ORDレコード
ord-a85f3a430f2c437fb71eff867eaedbde
出典データセット
uspto-grants-2014_11
特許番号
US08883782B2

関連ノート

読み込み中…