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Morpholine → (5S)-1-fluoro-7-(5-fluoro-3-pyridinyl)-3-(4-morpholinyl)spiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | (5-Fluoropyridin-3-yl)boronic acid | HCID 44717403 | — |
| 反応物 | (S)-7-bromo-3-chloro-1-fluoro-5'H-spiro[chromeno[2,3-c]pyridine-5,4' oxazol]-2'-amine | HCID 58466258 | — |
| 生成物 | (5S)-1-fluoro-7-(5-fluoro-3-pyridinyl)-3-(4-morpholinyl)spiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine | HCID 53465212 | — |
反応手順
The titled compound was synthesized by steps analogous to those described in Method CC4 above using (S)-7-bromo-3-chloro-1-fluoro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′ oxazol]-2′-amine (prepared as described in Method BB33), 5-fluoropyridin-3-ylboronic acid, and morpholine. MS m/z=452.1 [M+H]+. Calculated for C23H19F2N5O3: 451.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08883782B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-3512dcc7c042444ea290ceb8653fb063 |
| 出典メモ | uspto-grants-2014_11 |