Imidazole → HCID 86711274、化合物

HRID 336134ノート

反応式

HRID 336134 の反応式
N1C=CN=C1.[Si:6](Cl)([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7].[Br:14][CH2:15][CH:16]([OH:19])[CH:17]=[CH2:18].O>CN(C=O)C>[Br:14][CH2:15][CH:16]([O:19][Si:6]([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7])[CH:17]=[CH2:18]

参加物

6

反応物 4

HCID 795ImidazoleHCID 962WaterHCID 28928tert-Butyldimethylsilyl chlorideHCID 473501-Bromobut-3-en-2-ol

生成物 1

HCID 86711274HCID 86711274、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Imidazole (2.25 g) and tert-butyldimethylsilylchloride (4.75 g) were added to a solution of 1-bromo-3-buten-2-ol (4.5 g) in DMF (30 ml) at room temperature. The mixture was stirred at the same temperature for 16 hours, and water was added thereto, followed by extraction with hexane. The organic layer was washed with water, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound as a light-yellow, oily substance (7.0 g).

後処理

  1. extractionfollowed by extraction with hexane
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-580252e24eb04c6597d6f604f86dcf0f
出典データセット
uspto-grants-2014_11
特許番号
US08889666B2

反応ノート

読み込み中…