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HRID 336200作成日：2026年10月26日
Pyridine → (S)-1-(4-Chloro-phenyl)-6-oxo-piperidine-2-carboxylic acid (3-tert-butyl-isoxazol-5-yl)-amide
https://huagongshe.com/reaction/336200
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 3-Tert-butyl-1,2-oxazol-5-amine | HCID 2095694 | — |
| 反応物 | (S)-1-(4-Chloro-phenyl)-6-oxo-piperidine-2-carboxylic acid | HCID 42127104 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (S)-1-(4-Chloro-phenyl)-6-oxo-piperidine-2-carboxylic acid (3-tert-butyl-isoxazol-5-yl)-amide | HCID 58563752 | — |
反応手順
To a cold slurry of (S)-1-(4-Chloro-phenyl)-6-oxo-piperidine-2-carboxylic acid (0.2 g; 0.788 mmol) and 5-amino-3-tert-butylisoxazole (0.110 g; 0.788 mmol) in pyridine (0.956 mL; 11.820 mmol) is added phosphorous oxychloride (0.088 mL; 0.946 mmol). The mixture is stirred at 0° C. for 30 minutes and then diluted with water and extracted with ethyl acetate several times. The organics are combined and washed with water and brine, dried (Na2SO4), filtered and concentrated in vacuo. Purification by preparative HPLC affords title compound, m/z 376 [M+H+].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08889670B2 |
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| 出典データセット | uspto-grants-2014_11 |
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| ORD ID | ord-cc60fa4f3eba4880b745e202d0cd6112 |
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| 出典メモ | uspto-grants-2014_11 |
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