Hydrochloric Acid → (S)-Perhydro-azepine-2-carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide hydrochloride

HRID 336216ノート

反応式

HRID 336216 の反応式
[ClH:1].C(OC([N:9]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]1[C:16](=[O:27])[NH:17][C:18]1[CH:22]=[C:21]([C:23]([CH3:26])([CH3:25])[CH3:24])[O:20][N:19]=1)=O)(C)(C)C>O1CCOCC1.C(Cl)Cl>[ClH:1].[C:23]([C:21]1[O:20][N:19]=[C:18]([NH:17][C:16]([C@@H:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:9]2)=[O:27])[CH:22]=1)([CH3:26])([CH3:24])[CH3:25]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 58563977(S)-2-(5-tert-Butyl-isoxazol-3-ylcarbamoyl)-perhydro-azepine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 86660403(S)-Perhydro-azepine-2-carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide hydrochloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

反応条件

温度
0 °C

実験手順

HCl in dioxane (10.0 mL) is added slowly at 0° C. to a solution of (S)-2-(5-tert-butyl-isoxazol-3-ylcarbamoyl)-perhydro-azepine-1-carboxylic acid tert-butyl ester (0.70 g, 1.90 mmol) in DCM (15.0 mL). After stirring the reaction mixture at 0° C. for 3 hours, the solvent is removed under reduced pressure to afford the title product that is used in the next step without further purification.

後処理

  1. customthe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-7bbcfb5178c749599c07db71e04a255f
出典データセット
uspto-grants-2014_11
特許番号
US08889670B2

反応ノート

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