関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydroxylamine | HCID 787 | — |
| 反応物 | 2-Ethoxybenzonitrile | HCID 576922 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-ethoxy-N'-hydroxybenzenecarboximidamide | HCID 4056736 | 97.2% |
反応手順
Hydroxylamine (Fluka 55458; 50% in water; 4.08 mL; 67.95 mmol; 5 eq.) was added to a solution of 2-ethoxybenzonitrile (Fluorochem 18661; 2 g; 13.59 mmol; 1 eq.) in EtOH (30 mL) and the reaction mixture was stirred at 50° C. for 12 hours. Evaporation in vacuo gave a white solid, which was further dried under high vacuum to afford the title compound (2.38 g, 97%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08889668B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-0fbdd441fda74c4392ab37d553ef0602 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
