化工社化工社 化学情報印刷レポート · 研究参考用
Piperazine → 1-(4-Methoxypyridin-2-yl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | 2-Chloro-4-methoxypyridine | HCID 1991128 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 1-(4-Methoxypyridin-2-yl)piperazine | HCID 22648132 | 16.2% |
反応手順
46 mg 2-chloro-4-methoxy-pyridine and 277 mg piperazine in 2 mL n-methyl-2-pyrrolidinone were stirred 45 min at 140° C. and 30 min at 200° C. under microwave conditions. The reaction was diluted with water and purified by HPLC to give 10 mg desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08889677B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-63fe068426d742b984b82fa0b5cd9a08 |
| 出典メモ | uspto-grants-2014_11 |