Water → 2-Chloro-4-ethoxypyridine
反応式
[O-:1][CH2:2][CH3:3].[Na+].[Cl:5][C:6]1[CH:11]=[C:10](I)[CH:9]=[CH:8][N:7]=1.O>C(O)C>[Cl:5][C:6]1[CH:11]=[C:10]([O:1][CH2:2][CH3:3])[CH:9]=[CH:8][N:7]=1参加物
5
実験手順
33 ml sodium ethoxide was added to 19.2 g 2-chloro-4-iodopyridine in 150 mL ethanol. The reaction was refluxed overnight. Then water was added and extracted with tert-butyl-methylether. The organic layer was evaporated and the residue cleanded by chromatography on silica gel (petrolether/EtOAC:9/1) to yield 5 g of the desired compound.
後処理
- temperatureThe reaction was refluxed overnight
- extractionextracted with tert-butyl-methylether
- customThe organic layer was evaporated
出典と根拠
- ORDレコード
- ord-7e9bb253fda943609dc5924bd9ff0b20
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889677B2
反応ノート
読み込み中…