Piperazine → 1-(4-Ethoxy-pyridin-2-yl)-piperazine hydrochloride
反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[CH:11]=[CH:10][N:9]=1>C(O)CCC>[ClH:7].[CH2:15]([O:14][C:12]1[CH:11]=[CH:10][N:9]=[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[CH:13]=1)[CH3:16]参加物
4
反応条件
- 温度
- 115 °C
実験手順
860 mg piperazine was added to 350 mg 2-chloro-4-ethoxy-pyridine in 3.5 mL n-butanol. The reaction was stirred 1.5 days at 115° C. The reaction was filtered and the filtrate was washed with water and evaporated. 1N HCl was added to the residue and the precpipate was filtered to give 238 mg of the desired product. Rt: 0.3 min (method B), (M+H)+: 208
後処理
- filtrationThe reaction was filtered
- washthe filtrate was washed with water
- customevaporated
- addition1N HCl was added to the residue
- filtrationthe precpipate was filtered
出典と根拠
- ORDレコード
- ord-aa29e03f2d50462e8e58c5a4ee304661
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889677B2
反応ノート
読み込み中…